Short Course #1
Enantioselective, Electrochemical Sensors: Design, Response Characteristics, and Applications
Raluca-Ioana van Staden, Instructor
Please visit the Seattle meeting page for registration information. Early-Bird Registration rates are in effect until April 6, 2012. See a list of all Short courses offered at the Seattle meeting.
This course is intended for chemists, physicists, materials scientists, and engineers with an interest in applying electrochemical sensors to enantioanalysis. The discrimination between enantiomers using enantioanalysis is becoming one of the most important fields of modern analytical chemistry, especially for pharmaceutical analysis and clinical analysis/biomedical analysis. The course is best suited for an attendee who has basic knowledge of electrochemical sensors. The attendee will develop a basic understanding of the principles of molecular recognition of enantiomers, types of electrochemical sensors which can be used for enantioanalysis, design of enantioselective, electrochemical sensors, response characteristics, reliable application of the electrochemical sensors in enantioanalysis of compounds of pharmaceutical and clinical/biomedical interest. The topics to be covered include:
Principles of molecular recognition of enantiomers using electrochemical sensors,
Types of enantioselective, electrochemical sensors used in enantioanalysis: enantioselective, potentiometric membrane electrodes; enantioselective, amperometric sensors, stochastic sensors, biosensors, immunosensors, multimode sensors; general aspects,
Mechanism of potential development and enantioselectivity for potentiometric, enantioselective membrane electrodes,
Design of enantioselective, electrochemical sensors,
Response characteristics of enantioselective, electrochgemical sensors,
Simultaneous assay of enantiomers using enantioselective, electrochemical sensors,
Applications of enantioselective, electrochemical sensors in pharmaceutical and clinical/biomedical analysis.
About the Instructor
Raluca-Ioana van Staden is a Professor and Head of the Laboratory of Electrochemistry and PATLAB Bucharest in the National Institute of Research of Electrochemistry and Condensed Matter. She was an Associate Professor at the University of Pretoria (South Africa) and Assistant Professor at University of Bucharest. The author and co-author of more than 160 articles in journals especially in the fields of electrochemical sensors (ion-selective membrane electrodes, enantioselective, potentiometric membrane electrodes, biosensors, immunosensors), process technology and flow systems (flow and sequential injection analysis), of three book: “Quality and reliability in analytical chemistry” (CRC Press), “Electrochemical Sensors in Bioanalysis” (Marcel Dekker, Inc) and “Laboratory Auditing for Quality and Regulatory Compliance” (Taylor and Francis) as well as of numerous chapters in books most of them related to sensors technology, she serves on the Editorial Boards of Preparative Biochemistry and Biotechnology (Marcel Dekker, Inc.), and Sensors and Transducers Journal. Lately, she developed new types of sensors (potentiometric enantioselective membrane electrodes, biosensors and immunosensors) for the analysis of chiral drugs and she also did the modeling of interaction between enantiomer and chiral selector; she is also the initiator of simultaneous detection of enantiomers using (bio)sensors/sequential injection analysis systems. She received numerous international prizes from societies such as South African Chemical Institute (Raikes Medal), IUPAC, World International Laboratory, and from innovation salons from Geneva, Warsaw, Moscow, Brussels. The most important prize – WIPO AWARD FOR THE BEST WOMEN INVENTOR was received in Geneva in 2010, at the 38th Salon of Innovation and New Products for a microsensor capable to diagnosed 4 types of cancer in less than 6 minutes. She was invited for lectures in Romania (Bucharest), Belgium (Antwerpen), Austria (Vienna), Israel (Jerusalem), South Africa (Pretoria), USA (New Orleans, Boston) and Australia (Perth) and she has more than 200 presentations at international conferences and symposium in Europe, North and South America and Africa. A member of the American Chemical Society, International Society of Electrochemistry, The Electrochemical Society and Romanian Society of Chemistry, she received the B.Sc. degree (1992) and the Ph.D. degree (1997) in chemistry from the University of Bucharest, Romania, the B.Sc. degree (1996) in piano and musical education and the M.Sc. degree (1997) in musical composition from the Academy of Music, Bucharest, Romania.