Short Course #5
Micro/Nanofabrication of Chemical and Biosensors
Peter J. Hesketh, Gary W. Hunter and Zoraida P. Aguilar, Instructors
Please visit the PRiME meeting page for registration information. Early-Bird Registration rates are in effect until September 7, 2012. See a list of all Short courses offered at the Hawaii meeting.
This course will cover micro/nanofabrication techniques for chemical and biosensors. Fabrication processes including, physical vapor deposition, oxidation and diffusion in silicon, chemical vapor deposition, atomic layer deposition, plasma etching, in addition to photo and electron beam lithography. As nanotechnology is rapidly growing the methods for nanoscale fabrication of structures, including ion beam, electron beam, vapor-liquid-solid growth, and electroplating will be addressed.
Applications of micro/nanofabricated sensors range from aerospace, to biomedical and environmental chemical sensing. Case studies will be utilized to illustrating the important advantages of these miniature sensors. The combination of unique size-dependent physical and chemical properties and the introduction of multifunctionality on nanomaterials make them very promising technology. Nanoparticles are not only being used for sensing applications but can also be used for targeted drug/vaccine delivery at the same time (called nanotheranostics). The preparation of nanoparticles for nanobiosensors and nanotheranostics will be presented along with the surface modifications of nanoparticles with biomolecules such as antibodies, enzymes, oligonucleotides, and other molecules will also be presented. Characterization of the modified nanoparticles as well as evaluation of number of biomolecules bound to the surface will be reviewed.
About the Instructors
Peter J. Hesketh has over twenty five years experience in MEMS/NEMS and microfabricated sensors. He received a B.Sc. in Electrical and Electronic Engineering from the University of Leeds (1979) and was a Thouron Fellow at the University of Pennsylvania, obtaining an M.S. (1983) Ph.D. (1987) in Electrical Engineering. He worked in the Microsensor Group at the Physical Electronics Laboratory of Stanford Research Institute and then Teknekron Sensor Development Corporation before joining the faculty at the University of Illinois in 1990 in the Department of Electrical Engineering and Computer Science. He is currently a Professor of Mechanical Engineering at Georgia Institute of Technology, Member of the Parker H. Petit Institute for Bioengineering and Biosciences, and Director of the MEMS/NEMS Group in the School of Mechanical Engineering. His research interests include microcantilever chemical and biosensors, microvalves, miniature gas chromatography systems, and detection of contamination in foods. He has published over seventy journal papers and edited fifteen books. He is a Fellow of the AAAS, ASME, ECS, and a member of ASEE, AVS, and IEEE.
Gary W. Hunter is the Technical Lead for the Chemical Species Gas Sensors Team and Lead for Intelligent System Hardware in the Sensors and Electronics Branch at NASA Glenn Research Center. Since his arrival at NASA Glenn, he has been involved with the design, fabrication, and testing of sensors, esp., chemical species gas sensors. He has worked closely with academia and industry in developing a range of sensor technologies and sensor systems using a number of different sensor materials and sensing approaches. This work has included the use of both micro and nano technology as well as the integration of sensor technology into smart systems.
Dr. Hunterís contributions range from research to technical management in fields including engine emissions, environmental monitoring, spacesuit monitoring, fire detection, leak detection, and high temperature wireless sensors. Dr. Hunter has been active in the application of the resulting sensor technology both in NASA and industry with a range of activities involving the demonstration and application of sensor technology.
Dr. Hunter has taught short courses on chemical sensing technology; a high temperature sensors and electronics short course; co-authored three book chapters; has 6 patents; and has a significant number of papers, talks, and invited talks. He has been corecipient of two R&D 100 Awards for one of the most significant inventions/products of the year, two NASA Turning Goals into Reality Awards, and one Nano 50 Award. He is former Chair of the Sensors Division of the Electrochemical Society.
Zoraida P. Aguilar is currently a Principal Investigator/Study Director at Covance Laboratories, Inc. where she applies her knowledge and experiences in the clinical evaluation of various drugs and other medical products. She currently serves as consultant for biomedical and biological applications of nanomaterials at Ocean NanoTech where she was the former Director of Research and Development. While at Ocean NanoTech, she led the research and product development for biomedical and biosensors applications of inorganic nanomaterials. She was instrumental in the release of inorganic nanomaterials and related products for drug and vaccine delivery, biomedical imaging, and biosensors. Dr. Aguilar collaborated with various industries and universities worldwide in developing various biosensors and nanosensors for medical, environmental, and industrial applications. Dr. Aguilar has developed several patents in biosensors and nanoadjuvants. These patents are currently being used to develop various biosensors applications.
Dr. Aguilar has a PhD in Analytical Chemistry, a MS in Biochemistry, and multiple years of formal training in Molecular Biology and Biotechnology, clinical research, and microfabrication. She has hands-on experiences in microfluidics, instrument development, and lab-on-a-chip integration with instrument miniaturization. She was instrumental in the development of fully automated miniaturized electrochemical instruments. She has published more than forty papers in biosensors, nanosensors, and biomedical applications of nanomaterials. She is a recipient of the ACS graduate research fellowship in Analytical Chemistry in 2002, a Graduate Research Awardee from the Sigma Xi Scientific Research Society in 2003, and the Philippine Department of Science and Technology Returning Scientist Awardee in 2010-2011.