Nanometric Objects and Chip-Scale Platforms for Disease Diagnosis
by Marc D. Porter
Sunday, May 18, 2008 | Phoenix, AZ
The drive for early disease detection, the growing threat of bioterrorism, and a vast range of challenges more generally in biotechnology have markedly amplified the demand for ultrasensitive, high-speed diagnostic tests. This presentation describes efforts to develop platforms and readout methodologies that potentially address demands in this arena through a coupling of nanometric labeling with surface enhanced Raman spectroscopic, magnetic, and scanning probe microscopic readout concepts. Strategies will be described for the fabrication and read-out of chip-scale platforms and nanometric sized labels that can be used with each novel readout modality. Examples will focus on the use of protein arrays as platforms targeted for the rapid, ultralow level detection of cancer markers and viral pathogens. Each example will also discuss challenges related to sensitivity and nonspecific adsorption and to fluid manipulation.
Marc D. Porter is the USTAR Professor in the Department of Chemistry and of Chemical Engineering at the University of Utah. Dr. Porter received his doctorate from The Ohio State University in Analytical Chemistry in 1984. He then studied as a postdoctoral fellow at Bell Communications Research. Since 1986, he has been a member of the chemistry and of the chemical engineering faculty at Iowa State University where he was the Director of the Institute for Combinatorial Discovery and the Microanalytical Instrumentation Center. More recently, he served on the faculty of the Department of Chemistry and Biochemistry Arizona State University, directing the Center for Combinatorial Sciences at the Biodesign Institute. His research team focuses on the role of interfaces in analytical chemistry, including nanometric strategies for high speed, ultrasensitive biodiagnosts, electrochemically modulated liquid chromatography, electrocatalysis, organic monolayer films, chemically modified surfaces, scanning probe microscopies, infrared and Raman spectroscopies, and acoustic wave sensors. He has published ~200 scientific manuscripts, given over 400 research presentations, holds more than ten patents with several more pending, and is a co-founder of four companies. His teamís work has been supported by NSF, NIH, DAPRA, NASA, USDA, USDOE, and several companies, including IBM and Alcoa.