In “Approaches for the Electrochemical Interrogation of DNA-Based Sensors: A Critical Review,” Miguel Aller Pellitero, Alexander Shaver, and Netzahualcóyotl (Netz) Arroyo-Currás reviewed the specific advantages of the electroanalytical methods most commonly used for the interrogation of DNA-based sensors.

Arroyo-Currás, ECS member and associate editor, Journal of the Electrochemical Society sensors technical area, provided more background information to the article in response to questions from the ECS Blog.

What are DNA-based electrochemical sensors?

These are measurement platforms that employ any form of DNA as the molecular recognition element. We must remember that electrochemistry is extremely sensitive (for example, there is significant work regarding stochastic detection of single entities like molecules, nanoparticles and whole cells and viruses) but lacks specificity; thus, relying on the molecular binding properties of DNA allows us to selectively detect molecules even in complex biological environments. (more…)