ECS is proud to present Professor Christopher Muratore via webinar on January 27, 2021, at 1300h ET.
Two-dimensional Materials for Scalable Modular Electronic Pathogen Sensors
Prof. Christopher Muratore
Ohio Research Scholars Endowed Chair Professor
Chemical and Materials Engineering Department
University of Dayton, Ohio, U.S.
Date: January 27, 2021
Time: 1300h ET
The COVID-19 pandemic has shed light on the global need for inexpensive, simple-to-use pathogen tests accessible to individuals on a daily basis to move beyond point-of-care diagnostics in favor of methods even more readily available to all people.
We have developed a low-cost disposable electronic sensor for use by individuals with minimal training, and simple equipment to detect multiple pathogens in easily accessible biological samples, such as saliva. The devices were fabricated using scalable processes with the potential for economical mass production to utilize the sensitivity and surface chemistry of a two-dimensional MoS2 transducer for the attachment of antibody fragments in a conformation favorable for antigen binding. Ultra-thin layers (3 nm) of amorphous MoS2 were directly sputtered over the entire sensor chip at room temperature and laser annealed to create an array of semiconducting 2H-MoS2 active sensor regions between metal contacts. The semiconducting region was functionalized with monoclonal antibody Fab (fragment antigen binding) fragments derived from whole antibodies complementary to either SARS-CoV-2 S1 spike protein or Influenza A hemagglutinin. The high affinity of the antibody fragment base for the MoS2 transducer surface with some density of sulfur vacancies promoted antibody fragment chemisorption with antigen binding regions oriented for interaction with the sample. Electrical resistance measurements of sensors functionalized with antibody fragments and exposed to antigen concentrations ranging from 2-20,000 picograms per milliliter revealed selective responses in the presence of complementary antigens comparable to gold-standard diagnostics such as PCR analysis.
Benefits of attending the webinar
- On-demand functionalization for specific detection of any antigen (virus, bacteria, and/or protein) enabled by the modular sensor
- Novel scalable synthesis and fabrication approaches for inexpensive mass production of devices
- Multiplexed sensors allow instantaneous detection of multiple pathogens simultaneously
Prof. Christopher Muratore
Christopher Muratore is the Ohio Research Scholars Endowed Chair Professor in the Chemical and Materials Engineering Department at the University of Dayton, Ohio. Before joining the university, Professor Muratore spent nine years as a staff member at the Air Force Research Laboratory. He still works closely with sensor development and flexible electronics groups. Throughout his 20-year research career, Professor Muratore’s work has focused on developing an understanding of how to control the structure and properties of surfaces and interfaces and their impact on device or component performance in diverse applications. He has four patents, published over 90 peer-reviewed articles, and served as guest editor for Surface and Coatings Technology and Thin Solid Films over the past five years.
Read more about ECS Webinars.